Whole-known-network
<p><span class="h-card" translate="no"><a href="https://social.xenofem.me/users/nyx" class="u-url mention">@<span>nyx</span></a></span> <span class="h-card" translate="no"><a href="https://social.xenofem.me/users/JaneDough" class="u-url mention">@<span>JaneDough</span></a></span> it really does!</p>
<p><span class="h-card" translate="no"><a href="https://social.xenofem.me/users/nyx" class="u-url mention">@<span>nyx</span></a></span> <span class="h-card" translate="no"><a href="https://social.xenofem.me/users/JaneDough" class="u-url mention">@<span>JaneDough</span></a></span> re: psychoactive, aren't all sex steroids highly psychoactive? isn't this a big part of why we keep using them? ^^</p>
@whitequark@mastodon.social @JaneDough I didn't know which specific GABAergic substance it was that prog metabolizes to but you probably know a lot more about organic chem than me and may be aware that prog has a pretty wild metabolic cascade in general
<p><span class="h-card" translate="no"><a href="https://social.xenofem.me/users/nyx" class="u-url mention">@<span>nyx</span></a></span> <span class="h-card" translate="no"><a href="https://social.xenofem.me/users/JaneDough" class="u-url mention">@<span>JaneDough</span></a></span> it works orally too, which is how i've been doing it (can't snort the gel cap oily liquid lol. tho i tried crunching on it). make sure to do it on an empty stomach. works quite well IME</p>
<p><span class="h-card" translate="no"><a href="https://social.xenofem.me/users/nyx" class="u-url mention">@<span>nyx</span></a></span> <span class="h-card" translate="no"><a href="https://social.xenofem.me/users/JaneDough" class="u-url mention">@<span>JaneDough</span></a></span> oh, worth mentioning that with this much prog in you, some will be metabolized to androgens via the "backdoor androgen pathway" which, after careful examination, was most of why i was doing it in first place; have touched barely any since getting back on t</p>
@whitequark@mastodon.social @JaneDough I wish I could go deeper with it to fuck around with these effects (for science) because prog being psychoactive at all is very amusing to me but as I said above the experience of snorting it is miserable enough to limit me on its own lol. I might try making a nasal spray though, there's a paper detailing the process somewhere
<p><span class="h-card" translate="no"><a href="https://social.xenofem.me/users/nyx" class="u-url mention">@<span>nyx</span></a></span> <span class="h-card" translate="no"><a href="https://social.xenofem.me/users/JaneDough" class="u-url mention">@<span>JaneDough</span></a></span> p4 is metabolized to allopregnanolone which is GABAergic, which is how you get these effects</p>
<p><span class="h-card" translate="no"><a href="https://social.xenofem.me/users/nyx" class="u-url mention">@<span>nyx</span></a></span> <span class="h-card" translate="no"><a href="https://social.xenofem.me/users/JaneDough" class="u-url mention">@<span>JaneDough</span></a></span> the more you take the more extensive of a blackout you get, generally; given how quickly tolerance rises, you get into heavy blackout territory fast</p><p>i've never done anything concerning on it (the one major complaint i got was that the code i wrote was incomprehensible to the person watching it) but that might be a me thing</p>
<p><span class="h-card" translate="no"><a href="https://social.xenofem.me/users/nyx" class="u-url mention">@<span>nyx</span></a></span> <span class="h-card" translate="no"><a href="https://social.xenofem.me/users/JaneDough" class="u-url mention">@<span>JaneDough</span></a></span> it is 100% a result of prog, i have very extensive experience with anretrograde amnesia on it. it's temporary, benzo-like, and largely self-limiting IME.</p><p>annoyingly, had to deal with it recently in a hospital after someone i considered a friend screwed me over, i think they've never seen anything like it because they were baffled lol</p>